The South African, who has been attempting to make the qualifying mark for Berlin, also failed to reach last year's Beijing Olympics having won a long battle over the right to compete with able-bodied athletes.

The Paralympic gold medallist ran a season's best of 47.07sec in Lucerne last week - well short of the qualifying time of 45.95.

The South African suffered a boating accident in February which left him with head and facial injuries.

It hampered his training but he is still targeting London's 2012 Olympics.

He said: "Having not made the minimum qualifying time, I must resign myself to staying at home."

Pistorius will now probably aim for a place at the 2010 Commonwealth Games in Delhi.